PNRTs

should be classified as NE tumors in other sites, and proliferative rate can be an indicator of aggressive behavior/metastasis. Published by Elsevier Inc.”
“Purpose The primary objective of our study was to determine the minimum intravenous dose of carbetocin required to produce adequate uterine contraction in 95% of women (effective dose [ED](95)) undergoing elective Cesarean delivery (CD).\n\nMethods Eighty term pregnant women with low risk for postpartum hemorrhage (PPH) undergoing elective CD under spinal anesthesia were randomly allocated to receive carbetocin intravenously GDC-0068 PI3K/Akt/mTOR inhibitor in doses of 80 mu g, 90 mu g, 100 mu g, 110 mu g, or 120 mu g upon delivery. The consultant obstetrician evaluated the efficacy of the patient’s uterine tone as satisfactory or unsatisfactory. In case of unsatisfactory uterine tone, additional uterotonics were administered as per routine institutional practice. Side effects were monitored

during the study period. The main outcome AZD9291 purchase measure was satisfactory uterine tone at two minutes after carbetocin administration.\n\nResults Satisfactory uterine tone was obtained in 70 subjects (87%) within the dose range of 80-120 mu g of carbetocin. It was not possible to calculate the ED95 of carbetocin due to the even distribution of women with satisfactory uterine tone across all dose groups (P = 0.99). Similarly, the side effects were similar across all dose groups. There was a high overall incidence of hypotension

(55%) following the administration of carbetocin.\n\nConclusions In women at low risk for PPH undergoing elective CD, carbetocin doses of 80-120 mu g are similarly effective. There is a high incidence of hypotension associated with carbetocin in these doses, and further studies with doses lower than 80 mu g are warranted to assess the balance of efficacy and side effects. This trial was registered at www.clinicaltrials.gov (NCT01262742).”
“This prospective study intended to ascertain if cytochrome P450 dependent liver function is affected in early and late histological stages of primary biliary cirrhosis (PBC). The study included 32 female PBC patients (mean age 55.4 years, range 33-70) and Bafilomycin A1 16 aged-matched healthy women (mean age 52.6 years, range 38-65). In every subject a C-13-methacetin breath test (C-13-MBT) was applied, and the results were related to histological Ludwig’s staging system and several indices of liver disease severity comprising the MAYO-1, MAYO-2, MELD, and Child-Pugh score. The C-13-MBT differentiated healthy controls from the patients with Ludwig IV and Ludwig III histopathological stages of PBC. The most significant relationships (i.e. explaining >50% of the variance) were found between measurements of the momentary breath C-13 elimination from 6 to 18 minutes as well as the 15-min or 30-min cumulative elimination and the MAYO-1 or MAYO-2 scores.