However, studies have not yet been conducted to ascertain its role in prevention of hepatotoxicity. Aim: This study was planned to elucidate the role of wheat grass if any on liver function tests (LFT), antioxidants enzymes and histoarchitecture in hepatotoxicity conditions induced by Carbon tetra chloride (CCl4). Methods: 42 female

Wistar rats were divided into 7 groups. Group 1 (Normal control): Rats were given normal saline subcutaneously (SC). Group 2: CCl4 was administered SC at a dose of 2 ml/kg b.wt twice/week for 4 weeks. Group 3–6: – Rats in these groups received orally wheatgrass dissolved in water at different doses of 20 mg, 40 mg, 60 mg and 80 mg/100 g b.wt and CCl4 as was given to group 2 animals. Wheatgrass was started 2 weeks prior to first injection of CCl4. Group 7- Animals in this group received wheatgrass alone Small molecule library at a highest dose of 80 mg/100 g b.wt. The effects of different treatments were studied on LFT, Glutathione (GSH), lipid peroxidation (LPO), Catalase and superoxide dismutase (SOD) at end of 2 weeks and 4 weeks. Histological studies were also conducted. Results: The enzyme activity of ALP, Decitabine purchase AST, and ALT

were increased significantly at 2 and 4 weeks as compared to values in control group. Interestingly, supplementation of wheat grass at all doses brought down the already increased activity of ALT but there was more pronounced decrease with 80 mg dose of wheat grass at both the time duration s of 2 and 4 weeks. However, AST and ALP activity was found to be decreased significantly at 4 weeks following supplementation of wheat grass at doses ADAMTS5 ranging from 40–80 mg. Also, it was found that GSH level significantly decreased while LPO increased in CCl4 treated rats as compared to group1 (control).

In wheat grass treated groups, GSH level was increased while LPO decreased as compared to group 2. Histologically, there was necrosis, portal triaditis & lobular inflammation in CCl4 group. Therefore, protection was observed with wheat grass which may not be significant at 2 weeks but values were significant at 4 weeks. Conclusion: Wheat grass supplementation at a dose of 80 mg/100 g is effective in controlling hepatotoxicity induced by CCl4. Wheat grass and its extracts can be boon in preventing liver diseases Key Word(s): 1. Wheatgrass; 2. Carbon Tetrachloride; 3. Prevention; 4. Hepatotoxicity; Presenting Author: TAMSINNAOMI CARGILL Additional Authors: PREYA PATEL, LYNFA LANZON-MILLER, SANDRO LANZON-MILLER Corresponding Author: TAMSINNAOMI CARGILL, PREYA PATEL Affiliations: Milton Keynes Hospital Objective: Nasal bridle use is claimed to enable uninterrupted delivery of enteral nutrition and prevent unnecessary percutaneous endoscopic gastrostomies (PEGs). This study assesses the outcomes of patients fitted with nasal bridles at Milton Keynes Hospital.

Further research should be conducted on this topic. “
“Although endoscopic resection is widely accepted

as the curative selleck inhibitor treatment modality for early gastric cancer, secondary metachronous cancer may subsequently develop in the residual gastric mucosa. The preventive effect of Helicobacter pylori eradication on the development of metachronous gastric cancer in such cases remains controversial. The aim of this study was to determine the effect of H. pylori eradication on the development of metachronous gastric cancer after endoscopic resection of gastric neoplasm by a meta-analysis of all relevant studies. We performed a systematic literature search of PubMed, EMBASE, Google Scholar, and the Cochrane Library without language restrictions through March 31, 2014. We included all relevant articles, including prospective, observational,

and retrospective studies. Pooled estimates (odds ratios with 95% confidence see more intervals) were obtained using a random effects model. Thirteen studies were considered to be appropriate for this meta-analysis. Compared with the control group, the pooled odds ratio in the eradication group was 0.42 (95% confidence interval, 0.32–0.56), and there was no heterogeneity across the studies (p = .853, I2 = 0%). Subgroup analysis of three prospective trials also showed a lower incidence of metachronous cancer in the eradication group (odds ratio, 0.39; 95% confidence interval, 0.20–0.75). There was no evidence of publication bias in this meta-analysis. Helicobacter pylori eradication reduces the occurrence of

metachronous gastric cancer in patients who have undergone endoscopic resection. “
“A substantial number of reports published in the last year have contributed to a better understanding of both human and animal infection with non-Helicobacter pylori Helicobacter species (NHPH). Gastric infection of humans with Helicobacter suis and Helicobacter felis as well Clomifene as unidentified NHPH has been described to cause a chronic gastritis and a variety of clinical symptoms, whereas enterohepatic NHPH, including Helicobacter cinaedi, Helicobacter bilis, and Helicobacter canis, have been reported to be associated with human diseases such as bacteremia, cellulitis, cutaneous diseases, and fever of unknown origin in immunocompromised hosts. In various animal species, including dogs and laboratory mice, high rates of infection with NHPH were described. For gastric NHPH, mainly H. suis and H. felis infection was studied, revealing that differences in the immune response evoked in the host do exist when compared to Helicobacter pylori. Pathogenic mechanisms of infection with Helicobacter pullorum, H. bilis, and Helicobacter hepaticus were investigated, as well as immune responses involved in H. bilis-, Helicobacter typhlonius-, and H. hepaticus-induced intestinal inflammation. Complete genome sequences of Helicobacter heilmannii strain ASB1 and a H.