The aim of this study was to describe the etiology, endoscopic and histological features of benign esophageal ulcers. Methods: In this study, a total of 338 patients with esophageal ulcer were analyzed, which excluded the esophageal ulcers after sclerotherapy and those associated with esophageal malignancy. The clinical data include all medical esophagogastroduodenoscopies recorded at a single medical center from March 2003 to March 2011. Results: Of the 338 patients, 209 were men (61.8%) and 129 were women (38.2%) with a mean age of 58.2 years. The etiology of esophageal ulcers include the following: gastrointestinal

reflux disease (GERD) (59.5%), hiatus hernia, drug induced, candidal, marginal ulcer, caustic injury, multiple myeloma (MM), NVP-BKM120 ic50 foreign body, Crohn’s disease and unknown etiology. The size

of esophageal ulcers was 0.3 cm to 5 cm, and most of them were located in the lower thoracic esophagus (62.1%). The complications include hemorrhage, MLN8237 ic50 perforation, stricture and scar. Out of the 338 cases, 235 cases (69.5%) of esophageal biopsies were reviewed. Many of them were simple chronic inflammation (48%), chronic inflammation associated with tissue necrosis and atypical hyperplasia. Conclusion: The etiology of esophageal ulcer is very complex. GERD is the the most common causes of esophageal ulcers. Endoscopic and Histological features might be useful for dissection of etiology. Key Word(s): 1. esophageal ulcers; 2. etiology; 3. endoscopic features; Presenting Author: LEIJIA LI Additional Authors: JIN TAO, YING CHEN, SHUCHANG XU Corresponding Author: LEIJIA LI Affiliations: The Third Affiliated Hospital of Sun Yat-Sen University; Tongji Hospital Affiliated To Tongji University; Tongji Hospital affiliated to Tongji University Objective: To analyze

the reflux characteristics of Gastroesophageal reflux disease (GERD) patients with typical esophageal symptoms and extra-esophageal symptoms, and to explore the possible mechanism in pathogenesis of GERD symptoms. Methods: Fifty-seven learn more GERD patients and twenty-three healthy subjects (HS) as control group were enrolled in this study. The patients were divided into the following two groups according to different symptoms: group of esophageal symptoms (ES group, n = 19) and group of extra-esophageal symptoms (EES group, n = 38). The healthy subjects were control group (n = 23). All patients underwent 24 h impedance-pH monitoring and esophageal manometry. Results: The distal acid reflux of esophagus in patients with EES significantly decreased compared with ES group (P < 0.05). The percentage of synchronous contraction and esophageal peristalsis in EES group was significantly different from HS (P < 0.05), but there was no difference between ES group and the HS group (P > 0.05).