Unlike the US-FRAX 10-year hip fracture probabilities, which seem consistent with FRAX® estimates from other countries Selleck SCH727965 as well as US cohort studies, the 4-fracture 10-year probabilities produced by US-FRAX are higher than those
in other countries and higher than those observed in the Study of Osteoporotic Fractures (SOF; Meghan G. Table 2 Comparison of current (Olmsted County, MN) and revised fracture rates (annual incidence per 1,000), along with revised incidence ratios of any one of four major osteoporotic fracture to hip fracture Age group Hip Vertebra Humerus Forearm Incidence of major osteoporotic
fractures Ratio of 4 fracture to hip fracture alone Current [21] Revised Current [21] Revised Current [21] Revised Current [21] Revised Currenta Revisedb Currenta Revisedb Women 50–54 0.66 0.29 2.25 0.64 0.66 0.66 2.91 2.91 5.83 4.05 8.83 13.97 55–59 0.83 0.57 2.15 1.32 1.65 1.65 4.30 4.30 8.04 7.06 9.69 12.39 find more 60–64 1.65 1.05 3.49 1.24 1.65 1.65 8.08 8.08 13.38 10.82 8.11 10.30 65–69 2.21 2.03 6.82 2.33 1.40 1.40 8.22 8.22 15.85 11.88 7.17 5.85 70–74 2.75 3.94 11.67 4.73 3.43 3.43 8.24 8.24 22.18 17.29 8.07 4.39 75–79 8.61
7.93 15.66 5.23 2.44 2.44 8.35 8.35 28.05 19.16 3.26 2.42 80–84 18.38 14.47 25.79 6.22 5.48 5.48 8.70 8.70 46.68 27.90 2.54 1.93 85+ 24.88 26.06 31.32 10.95 4.98 4.98 8.49 8.49 55.74 40.38 2.24 Methane monooxygenase 1.55 Men 50–54 0.40 0.28 0.94 0.43 0.27 0.27 1.47 1.47 2.77 2.21 6.93 7.89 55–59 0.32 0.38 1.60 0.46 0.48 0.48 0.64 0.64 2.74 1.76 8.56 4.63 60–64 0.81 0.66 0.81 1.78 0.81 0.81 1.41 1.41 3.46 4.19 4.27 6.35 65–69 1.89 1.18 4.97 1.14 1.42 1.42 0.95 0.95 7.85 3.99 4.15 3.38 70–74 1.60 2.10 4.15 2.14 1.60 1.60 0.64 0.64 6.79 5.51 4.24 2.62 75–79 5.34 4.02 6.68 3.50 1.34 1.34 0.45 0.45 11.74 7.45 2.20 1.85 80–84 5.97 8.13 15.67 3.58 0.75 0.75 1.49 1.49 19.10 11.16 3.20 1.37 85+ 15.01 16.30 25.33 12.39 1.88 1.88 0.94 0.94 34.53 25.21 2.30 1.55 aThe risk of any one of four major osteoporotic fractures (proximal femur, clinical vertebral, proximal humerus, and distal radius) calculated from the sum of risks for 4 individual fracture types, from Olmstead County, MN [21], after overlap discount applied (see text) bThe sum of revised risks of any one of four major osteoporotic fractures, after overlap discount applied (see text) In order to clarify this discrepancy, a review of the data currently used for the US-FRAX implementation was conducted.