These guidelines contain a chapter on general information on dental care of patients with EB, followed by a chapter explaining the precautions that should be taken into account when treating patients with each subtype of EB, as well as recommendations for dental treatment. The appendix includes a glossary, general information on EB, and a description of its oral

manifestations. To provide the users with information on the current best practices for managing the oral health care of people living with EB. Specialists in Paediatric Dentistry, Special Care Dentistry, Orthodontics, Oral and Maxillofacial Surgery, Rehabilitation and General Dental Practitioners, Dental hygienists, selleck chemicals llc Paediatricians, Dermatologists, Dietitians, parents, and those living with inherited epidermolysis bullosa. These guidelines can be applied to all patients diagnosed with epidermolysis bullosa. As such, the guideline considers information for all four major types of EB: EB simplex, junctional EB,

dystrophic EB, and Kindler syndrome. To formulate the recommendations, from the selected studies, the SIGN Guidelines were used. LEVELS OF EVIDENCE 1++ High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of www.selleckchem.com/products/nu7441.html bias 1+ Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1− Meta-analyses, systematic reviews, or RCTs with a high risk of bias 2++ High-quality systematic reviews of case–control or cohort studies High-quality case–control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal 2+ Well-conducted case–control or cohort studies with a low Tau-protein kinase risk of confounding or bias and a moderate probability that the relationship is causal 2− Case–control or cohort studies with a high risk of confounding

or bias and a significant risk that the relationship is not causal 3 Nonanalytic studies, for example, case reports, case series 4 Expert opinion GRADES OF RECOMMENDATION Note: The grade of recommendation relates to the strength of the evidence on which the recommendation is based. It does not reflect the clinical importance of the recommendation. GOOD PRACTICE POINTS Fiftieth Guideline Developer’s Handbook, NHS Scottish Intercollegiate Guidelines Network SIGN. Revised Edition January 2008. A preventive protocol is today’s dental management approach of choice1-3. The approach to dental treatment for patients with epidermolysis bullosa (EB), in particular for those with the more severe types, has changed dramatically over the last 30 years. Crawford et al.4 considered extraction of all teeth to be the treatment of choice for patients with RDEB.