The relative possibility of RA was 3. 0 in men and women carrying rs2377422 TT genotype with SE alleles, and 9. 06 in persons carrying rs2377422 CC genotype with SE genes. The interaction among rs2377422 and SE alleles was considerable, as measured with the attributable proportion due to interaction. Syk inhibition DCIR gene transcription quantification assessment further proved the dominant result of rs2480256 CC genotype on DCIR expression levels in RA clients. Conclusions: Our study gives proof for association involving DCIR rs2377422 and RA, particularly with anti CCP bad RA in non Caucasian populations.

P23 Association in between serum amount of Vitamin D with autoantibodies expression, disease activity and bone mineral density in patients with Systemic Lupus Erythematosus Handono Kalim1, Singgih Wahono1, Putra Suryana BP1, Lenny Puspitasari1, Fajar Hadi Wijayanto1, Kusworini Handono2 1Rheumato Immunology Division, Department of Inner Medication, Brawijaya University, Malang, Indonesia, GSK-3 beta pathway 2Department of Clinical Pathology Faculty of Medicine, Brawijaya University, Malang, Indonesia Arthritis Research & Therapy 2012, 14 23 Page 31 of 54 Backround: Vitamin D defficiency has been reported to have unfavorable association with clinical manifestation and ailment action of SLE. Vit D has an important role in the pathogenesis of SLE and it is necessary to give vit D supplementation to the individuals. The objective of our study was to determine the association concerning serum vitamin D level with auto antibodies expression, illness action and bone mineral density in SLE individuals.

People and methods: 55 female people with SLE were recruited from Clinic of Rheumato Immunology, Saiful Anwar Hospital, Malang, Indonesia. Mean age of the people 31. 12 years with duration of illness 18,4 months. Serum vitamin D3 degree was assayed using ELISA method. Anti ds DNA and Anti Cardiolipin antibodies Gene expression were assayed using ELISA method. Sickness action assessed by SLE ailment exercise index and BMD was assessed by bone densitometry using DEXA. Association in between variables were analyzed using Spearman correlation. Result: The mean of serum 25 D3 degree was 22. 80 _ 16,23 ng/mL. 14 clients had vitamin D deficiency, 34 patients had vitamin D insufficiency, and 7 people had normal vitamin D amounts. There were major difference level of anti dsDNA antibodies and IgM ACA in clients with vitamin D insufficiency and vitamin D defisiency.

Serum degree of 25 D3 were negatively related with level of anti dsDNA and IgM ACA. The mean of SLEDAI was 15,0 10. 46. Serum vitamin D amounts were inversely correlated with SLEDAI. Normal BMD at lumbal spine found in 21 clients. 26 patients were osteopenia, and peptide calculator 8 people were osteoporosis. At femoral neck, 25 clients had normal BMD, 23 patients were osteopenia, 7 individuals were osteoporosis. There were no sizeable correlation concerning vitamin D degree and BMD at lumbal spine and at femoral neck. Conclusion: A large proportion ofSLE clients had low vitamin D levels. There were positive association among vit D degree and autoantibodies expression in SLE and negative association amongst serum vitamin D levels with SLEDAI.