Recently, the Valve Academic Research Consortium (VARC) issued a consensus report suggesting definitions for vascular complications to allow standardization and comparison between studies.9 Major bleeding complications occurred in 16.2% of TAVR patients in the PARTNER B trial and 11.0% of TAVR patients in the PARTNER A trial.2, 3

Bleeding complications tend to occur more frequently and be more severe in transapical cases. Follow-up of patients who experience and survive a major bleeding event shows that it has an adverse effect on midterm survival.10 Avoiding major vascular complications requires careful patient screening and selection. Since complications can never be completely Inhibitors,research,lifescience,medical eliminated, it is important for the TAVR implanter to ensure that large occlusion balloons, covered stents, surgical instruments, and blood are readily available and to inform ancillary staff of plans should complications arise. Most importantly, the operator should not hesitate to use non-iliofemoral access if Inhibitors,research,lifescience,medical the iliofemoral vessels are inadequate. Conflict of Interest Disclosure: All authors have

completed and submitted the Methodist DeBakey Cardiovascular Journal Conflict of Interest Statement and the following was reported: Dr. Reardon is a consultant for Medtronics and is a principal investigator for the CoreValve® US Pivotal Trial. Funding/Support: The authors have no Inhibitors,research,lifescience,medical funding disclosures. Contributor Information Basel Ramlawi, Methodist DeBakey Heart & Vascular Center, The

Methodist Hospital, Houston, Texas. Javier E. Anaya-Ayala, Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas. Michael J. Reardon, Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas.
Medical scientists and cardiologists in particular have Inhibitors,research,lifescience,medical always been excited about breakthrough technologies Inhibitors,research,lifescience,medical that offer new modalities for treating common diseases. In cardiac surgery, the advent of the heart-lung machine led to groundbreaking procedures such as valve repair and replacement, www.selleckchem.com/products/ipi-145-ink1197.html coronary artery bypass, and heart transplantation. Interventional cardiology as a field began in 1977 when Andreas Gruntzig first began the practice of balloon coronary angioplasty. Coronary stent placement in the 1990s and drug-eluting CP-673451 molecular weight stent implantation in the 2000s took center stage in this field — and in cardiology in general. As complication rates declined precipitously and the indications for stent placement narrowed somewhat, interventional cardiologists searched elsewhere for new frontiers. The refinement of new imaging modalities such as echocardiography and magnetic resonance imaging focused attention on structural abnormalities of the heart. At the same time, an aging population made degenerative aortic stenosis a prime target for further therapeutic advances. In an often-cited statement in his 1931 textbook of cardiology, Paul Dudley White wrote: “There is no treatment for aortic stenosis.