Recent evidence from patient populations suggests that chunking motor sequences is supported by the basal ganglia (Tremblay et al., 2010 and Boyd et al., 2009), consistent with a dopamine-dependent mechanism that is reliant on the sensorimotor putamen. GS-1101 nmr Parkinson disease (PD) patients are known to be impaired in generating previously automatic movements

due to lesions of sensorimotor dopaminergic nuclei in the basal ganglia. Chunking, which emerges as a feature of practiced movements, is blocked in unmedicated patients performing a sequencing task relative to both age-matched controls and PD patients on L-DOPA (Tremblay et al., 2010). Of critical importance, all groups were able to demonstrate learning, but only patients without medication were unable to translate single motor responses into chunks. In other words, the absence of chunking does not necessarily restrict all potential avenues for sequence learning, such as cortically based associative MEK inhibitor side effects learning, which elderly subjects were likely using despite their lack of chunking during sequence learning (Verwey, 2010). Similarly, Boyd et al. (2009) found that chunking was impaired in patients with chronic middle cerebral artery (MCA) stroke involving the basal

ganglia when they used their nonhemiparetic arm. The involvement of the sensorimotor striatum in the expression of chunking through well-practiced procedures has been studied extensively in both rats and nonhuman primates (Graybiel, 2008 and Yin and Knowlton, 2006). Neural firing patterns recorded in the rat dorsolateral caudoputamen display a task-bracketing distribution, with phasic firing at the start and finish of T-maze navigation (Barnes et al., 2005 and Jog et al., 1999). Further, the expression of these phasic patterns in

the dorsolateral caudoputamen is linked to learning motor components of navigation behavior (Thorn et al., 2010). Task-bracketing activity sharpens throughout early learning and occurs in parallel with phasic patterns in the associative dorsomedial caudoputamen. Critically, once cue-based associations are learned, dorsomedial firing wanes and performance is correlated with the ongoing phasic dorsolateral activity. This suggests that firing in the see more dorsolateral caudoputamen supports the expression of habitual actions (Thorn et al., 2010). Our finding that φ increases with sequence learning is consistent with these results, suggesting that increased activation from the bilateral putamen is necessary for the strengthening of motor-motor associations that are associated with fluid sequential behavior. There is growing evidence that a frontoparietal network also supports chunking but in a fundamentally different way (Pammi et al., 2012; Verwey et al., 2010, 2011; Bo and Seidler, 2009 and Bo et al., 2009).