Poorly reliable measurements according the definition of Boursier et al. 2013 (Hepatology) give at least Journal and year were excluded from our study. Marginal donors were classified according the definition of Eurotrans-plant: age (>65 years), BMI (>30), Time of ventilation (>7 days), Serum sodium (>165mmol/L), Serum ASAT (>105U/L), Serum ALAT (>90U/L) and Serum Bilirubin (>3mg/L). Results 44 potential donors (including 29 marginal donors, 66.0%) were screened. 33 grafts were finally selected for OLT including 12 non-marginal (12/15; 80%) and 21 marginal (21/29, 72.4%) grafts. In marginal donors median LS were 7.6 kPA(IQR 6.2-10.9)(range2.9-20) in livers selected for transplantation and 10.9 kPA(IQR 7.5-12.1)(range
5.6-20) in excluded livers (p<0.05). LS showed good correlation with macroscopic finding http://www.selleckchem.com/products/ganetespib-sta-9090.html such as edge, surface and consistence (Table 1). In grafts with normal edge LS were 7.3kPa (range3.9-20) in grafts
suitable for oLT (20/22 donors) and 13.8 kPA (range7.9-19.6) in grafts refused for oLT (2/22 donors).In grafts with abnormal edge LS were 6.7kPa (range2.9-8.2) in grafts suitable for oLT (4/12 donors) and 10.9 kPA (range5.6-19.8) in grafts refused for oLT (8/12 donors). Results for surface and consistence are displayed in table 1. Table 1 (please see Images) Conclusions LS can be helpful to identify potential deceased marginal liver donors. FurthermoreTE might be a valuable tool to identify suitable grafts among donor livers with abnormal macroscopic findings. Disclosures: Simona Bota – Speaking and Teaching: MK-8669 purchase Janssen Pharmaceutica, Boehringer Ingelheim, Bristol-Myers Squibb Thomas
Reiberger – Grant/Research Support: Roche, Gilead, MSD, Phenex; Speaking and Teaching: Roche, Gilead, MSD Mattias Mandorfer – Consulting: Janssen ; Grant/Research Support: Roche, MSD; Speaking and Teaching: Boehringer Ingelheim, Roche, Bristol-Myers Squibb, Janssen Michael Trauner – Advisory Committees or Review Panels: MSD, Janssen, Gilead, Abbvie; Consulting: Phenex; Grant/Research Support: Intercept, Falk Pharma, Albireo; Patent Held/Filed: Med Uni Graz (norUDCA); Speaking and Teaching: Falk Foundation, Roche, Gilead Markus Peck-Radosavljevic – Advisory Committees or Review Panels: Bayer, Gilead, selleck inhibitor Janssen, BMS, AbbVie; Consulting: Bayer, Boehringer-Ingelheim, Jennerex, Eli Lilly, AbbVie; Grant/Research Support: Bayer, Roche, Gilead, MSD; Speaking and Teaching: Bayer, Roche, Gilead, MSD, Eli Lilly The following people have nothing to disclose: Remy Schwarzer, Rafael Paternostro, Jagdeep Singh, Tamara Braunschmid, Ferdinand Mühlbacher, Clemens Kietaibl, Gabriela Berlakovich, Arnulf Ferlitsch Introduction: Initial poor function (IPF) is a term used to describe temporary malfunction of the transplanted liver. Over 15 different definitions of IPF can be found in the literature and there is only a few cases in which its impact on survival is described.