of India for funding. The authors also acknowledge Department of Pharmaceutical Sciences, Dibrugarh University for providing instrumental facilities for the successful analysis of the AgNPs synthesized during the study. “
“Periodontal disease is an infection that involves the inhibitors inflammatory process and the immune response. The presence of periodontal

pathogens such as Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans are responsible for periodontal destruction. It refers to acute and chronic disorder of the soft tissues surrounding the teeth which eventually leads to loss of supporting bone. 1 Apart from scaling and planning, systemic antibiotic therapy is employed in treating periodontitis. 2 Systemic antimicrobials Enzalutamide research buy such as adjuncts to mechanical therapy have had a positive effect on clinical as well as microbiological parameters. 3 But the impact of this approach is reduced by the fact that the antibiotic

is normally difficult to maintain in therapeutic concentrations at the site over the course of the treatment period. Due to these negative effects, the use of local drug delivery devices containing antibiotics may be explored. These devices can maintain extremely high local concentrations of drug for one month. Several implantable devices like fibers, 4 films and gels were studied. Various biodegradable polymers such as poly(glycolidecold-lactide), polyester poly (capralactone), glycerol mono-oleate, crosslinked atelo-collagen, hydroxypropylcellulose were employed as drug carriers. The purpose Selleck Rigosertib of the study is to develop biodegradable delivery system for Moxifloxacin HCl, dispersed in chitosan films which were further crosslinked with different concentrations of sodium citrate for different

crosslinking time. Thus the films could be easily placed into periodontal pocket, and be capable of delivering therapeutic concentration of Moxifloxacin for prolonged period of time with a much lower dose, hence having see more untoward side effects. Chitosan is a (1,4)-2 amino-2-deoxy b-D glucan, with similar structural characteristics as that of glucosaminoglycans. It is a hydrophilic biopolymer obtained by alkaline deacetylation of chitin, a major component of arthropod shells, and possesses favourable properties such as nontoxicity, biocompatibility, bioadhesivity, biodegradability,5 excellent mucoadhesive and permeation enhancing effect across biological surfaces. Moreover, chitosan itself possesses antimicrobial activity. It is reported to form complex with negatively charged moieties such as sodium carboxymethylcellulose, citrates, pectin, acacia, agar, sodium caprylate, stearic acid, gluteraldehyde, sodium tripolyphosphate, lactic acid, malic acid and alginic acid.