Mid-gut; 4. ulcerative colitis; Presenting Author: XIAOCANG CAO Additional Authors: JEAN-FRÉDÉRIC COLOMBEL Corresponding Author: XIAOCANG CAO Affiliations: ttianjin medicl university general hospital; Université Lille Nord de France, Objective: De novo inflammatory bowel disease (IBD) arises following solid organ transplant (SOT) unbelievably although increased immunosuppression during post-transplantation, but not infrequently as there is ACP-196 solubility dmso increasing recognition of de novo IBD in this entity recently. It has an incidence that is an order of magnitude higher than that seen in the general population worldwide

but the magnitude of this risk has yet to be determined. Methods: MEDLINE, Cochrane Library, and EMBASE and international conference abstracts are searched and all case reports and cohort studies are included as randomized controlled trials would be difficult for this entity. Results: A review of the

current literature to date yields a total of 78 reported cases of de novo IBD among 7555 transplants, 58 are in orthotopic liver transplantation (OLT) patients, 13 in kidney, 5 in heart, 1 in BMT and 1 in small bowel transplantation. These cases manifest as UC more commonly than CD as these cases are labeled as ulcerative colitis click here (UC) in 51, Crohn’s disease (CD) in 19 and indeterminate colitis in 8 patients. Over 65% of cases following OLT occur when the indication for transplant is PSC or autoimmune hepatitis. The mean lag time between transplant and IBD diagnosis was 63.7 (10.4–240.5) months. The annual incidence is estimated around 0.2%. Among liver recipients, the annual incidence is much higher at 100 per 100,000 vs. 5.8 per 100,000 in the non-liver organ recipients, and cumulative rates are substantially higher among patients with PSC or AIH (30%) relative to others (10%) following OLT. These cases following OLT are more likely to occur in those patients who has experienced a CMV infection or who has a CMV mismatch, while CellCept and tacrolimus

exposure seem be related with those after kidney transplantation. MCE Conclusion: De novo IBD is not limited to OLT recipients. These cases occur in OLT recipients at a rate much higher than the general population and other SOT recipients. It pose management difficulties post-operation since patients diagnosed with de novo IBD require additional medications beyond their transplant immunosuppression for treatment, recognition of this entity has important clinical implications. Interrogations of larger transplant databases would yield some information which could contribute to confirm previously identified risk factors. Key Word(s): 1. IBD; 2. organ transplant; 3. immunosuppression; 4.