Methods. Thirty subjects with controlled persistent asthma were compared with 30 non-asthmatic subjects who were matched by age and sex. Individuals who had received psychiatric treatment, demonstrated chronic musculoskeletal pain, had limited joint movements, or showed vestibular or other equilibrium disorders were excluded from both the
groups to avoid biomechanical bias in the dynamic posturography. Balance control was evaluated with the subject standing still on a force platform under four different sensory test conditions. These conditions combined the subject’s LDN-193189 in vitro eyes being opened or closed with a fixed or mobile force platform. A mobile platform provides a somatosensory perturbation, and when associated with the eyes closed condition, only vestibular information is available to moderate balance control. Sensory manipulation provides a more sensitive
condition to differentiate postural control between populations or pathologies. Data were sampled SB203580 mouse at 100 Hz in three 20-second trials and four postural conditions were assessed. The center of pressure (CoP) displacement values were used to calculate area and velocity in the medial-lateral and forward-backward directions. A two-factor analysis of variance with repeated measurements was applied to the data. Results. In comparison to the control group, the asthma group demonstrated a greater area of CoP displacement in conditions using the mobile force platform (with eyes opened or closed) and a higher velocity in forward-backward direction on the mobile platform with the eyes closed. Conclusion. Asthmatic individuals presented a greater area for the CoP displacement under somatosensory perturbations and a higher velocity in the forward-backward direction when vestibular information only was made available. Our data suggest that balance needs to be evaluated in asthmatic patients.”
“Objectives
Phase I: To evaluate levels of prostaglandin E-2 (PGE(2)), nitrites and nitrates (NOx), tumor necrosis factor-alpha (TNF-alpha) and expression of inducible cyclooxygenase (COX-2), nitric oxide synthase (NOS-2), and matrix metalloproteinases (MMP-3 and -9) in canine aqueous humor following repeated anterior chamber paracenteses (ACP). Phase II: to evaluate the effect of carprofen on PGE(2), NOx, and TNF-alpha in canine aqueous humor following https://www.selleckchem.com/screening/fda-approved-drug-library.html ACP.
Animals studied Four beagles in phase I and 8 beagles in phase II.
Procedures Phase I: ACP was performed at time (T) 0, 4 and 8 h. Phase II: A randomized, placebo-controlled cross-over design with four dogs per group where carprofen was given 4.4 mg/kg/day on day (D) 1, 2 and 3. ACP was performed at T0 and T1.5 on D3. Statistical analysis was performed with repeated measures ANOVA and post hoc Tukey-Kramer multiple-comparison procedure. In phase II, TNF-alpha level was analyzed with a Wilcoxon signed-rank test.
Results Phase I: PGE(2) significantly increased (P < 0.0001) to plateau at T4. NOX was decreased at T4 (P < 0.