Livin (BIRC7), a novel identified member of IAP family, selectively binds the endogenous IAP antagonist SMAC and caspase-3, caspase-7, and caspase-9, as a result, inhibits apoptosis [19–21]. Survivin can also bind the effector cell death proteases caspases-3 and -7 and inhibit caspase activity and cell death. Furthermore, Survivin-(hepatitis B X-interacting protein) complexes can bind pro-caspase-9 and selectively suppresses apoptosis via the mitochondria/cytochrome c pathway [19, 22]. Livin and Survivin expressions were found in primary

and cultured tumor cells and their overexpression was associated with poor prognosis [23–25]. In this study, Livin expression was markedly inhibited by oxymatrine in a dose-dependent manner, while the expression of Survivin was only down-regulated at a relative high dose of oxymatrine. Stattic mouse Conclusions In this study, a dose- and time-dependent Vactosertib mw oxymatrine-induced pancreatic cancer cell death via increasing pro-apoptotic Bax expression and decreasing anti-apoptotic Bcl-2 and Bcl-xS expression result in the release of cytochrome to cytosol, followed by activation of caspapse-3 and finally lead to cell apoptosis. Moreover, down-regulation of IAP family members (Livin and Survivin) is likely to be involved in the oxymatrine-induced apoptosis. These findings may provide

a promising approach of pancreatic cancer’s therapy based on traditional Chinese medicine. Acknowledgements This work was supported by Key project of Administration of Traditional Chinese Medicine of Zhejiang province MDV3100 supplier (No. 2005Z007). References 1. Hidalgo M: Pancreatic cancer. The

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