Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia cell proliferation, rheumatoid arthritis and pulmonary fibrosis. Therefore, CXCR4 inhibitors have potential as novel therapeutics for the treatment of these diseases as well as HIV infection.”
“The total power loss density of a soft magnetic alloy with wt. % 49 Co-49 Fe-2 V was investigated. Measured loss data of strip material with thickness 0.1 mm were in good agreement with the statistical loss theory that is based on separation of losses into hysteresis, eddy current, and excess contributions.

As a standard reference material a NU7026 low-loss 2.7 wt. % Si-Fe nonoriented electrical steel (with P = 2.25 W/kg at 1.5 T and 50 Hz at thickness 0.35 mm) was also investigated. The results indicate that the amount of excess loss is distinctly higher for the SiFe electrical steel while hysteresis loss is slightly lower. As a consequence the total loss density is lower for the CoFe alloy above a limit buy Nocodazole value of frequency that is identified

for material thicknesses 0.1 mm, 0.2 mm, and 0.35 mm at several induction values. This result makes the material attractive for an increasing number of applications where energy efficiency is important. Kerr-microscopic images of the magnetic domain structure of the two materials show smaller domains of the CoFe alloy as the potential reason for the difference in excess losses. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3537956]“
“Background: Implantable heart rhythm devices are susceptible to interference in hospitals where electromagnetic interference (EMI) sources are ubiquitous.

Case Description: We report three cases in which EMI from the external defibrillator caused the inability to interrogate Boston Scientific

cardiac resynchronization therapy-pacemaker (CRT-P) devices. We have documented interference AZD5363 chemical structure with the Boston Scientific CRT-P Contact Renewal device model numbers H120/H125 (Natick, MA, USA) and two brands of external defibrillators: the Philips Heartstart XL model number M4735A (Andover, MA, USA) and the Hewlett-Packard Codemaster model number M1722B (Palo Alto, CA, USA). For device implants, we routinely place external pacing pads with the external defibrillator in the “”standby”" mode for transcutaneous pacing so that only the pacer “”start/stop”" button needs to be pressed when necessary. We have not been able to interrogate three consecutive Boston Scientific CRT-P devices prior to closure while the external defibrillator had the back-up pacing mode on “”standby.”" In our initial case, a second device was opened because this interaction was not recognized.