However, no significant multiplicative interaction was observed (Table 5). In females in each BFP group with BMI < 19.8, there was no significant multiplicative interaction for FL (data not shown). Table 6 (for males) and Table 7 (for females) indicate the results of stratification of male https://www.selleckchem.com/products/midostaurin-pkc412.html and female BMI and BFP in separate 2 × 2 tables, as well as evaluation of the additive interaction. When setting BMI < 23.2

and BFP < 22.3 (both low-value groups) as references, the OR of FL among males increased with BMI ≥ 23.2 and BFP ≥ 22.3 (both high-value groups) (adjusted OR: 4.7 [95% CI 3.53–6.26]); the synergy index was 1.77, and a significant additive interaction was recognized (Table 6). In females, when setting BMI < 20.9 and BFP < 28.4 (both low-value groups) as references, the OR of FL increased with BMI ≥ 20.9 and BFP ≥ 28.4 (both high-value groups) (adjusted OR: 3.2 [95% CI 2.05–4.84]); the synergy index was 0.49, indicating lack of a significant additive interaction (Table 7). In this study, we focused on BMI and BFP relating to weight and weight gain ≥ 10 kg since the age of 20. Regardless of gender, BMI, BFP and weight gain ≥ 10 kg since 20 years of age were significantly associated with FL in models 1 and 2. This finding on the association between FL and BMI/BFP concurs with the results of many previous studies.[18-21] However, we

could find no preceding Vemurafenib ic50 study showing any association between weight gain ≥ 10 kg since the age of 20 and FL. Some studies, which treated short-term weight gain as a variable, reported its significant association with FL, while other investigations report significant associations between FL and weight gain within why the normal weight ranges.[5-9]

Our analysis of the association between weight gain ≥ 10 kg since the age of 20 and FL may be the first to target Japanese adults. As it is common to find Japanese adults aged 30 years or over who have gained more than 10 kg in weight since the age of 20 on routine health checkups, this variable is likely to be a subject of future investigations of factors associated with FL. With regard to BMI and BFP, we assumed that subjects with high BMI do not necessarily have high BFP values. Individuals with the same weight differ in the weight of fat, bones, blood and organs, all of which constitute body weight. Our analysis results indicated a gender difference, in which no significant association between FL and BMI or BFP was observed among females, while the OR of FL among males significantly increased along with higher BMI and/or BFP. Regarding the degree of association with FL by gender, our observation indicated that males are more strongly associated with FL than females. Moreover, the results of stratified analysis by 2 × 3 and 2 × 2 tables also indicated gender differences in the increase of adjusted OR as well as in the interaction between BMI and BFP.