For each set of simulated data, the table also captures spectral and weights correlations and the correlations of LCModel estimates with the ground truth. Note the high spectral and weights correlations revealing the ability of ICA to resolve MR spectra and extract ICs substantially resembling underlying basis spectra. Also notice LCModel results are strongly predicated upon the basis spectra underlying the simulated data. Table 1 Results from 193 spectra simulation experiments: Results Inhibitors,research,lifescience,medical from simulated data generated with LCModel and GAVA basis shown. Notice the spectral correlations

between the modeled spectra are not the same across metabolites. Both the LCModel and ICA estimates … The results from analysis

of the data generated using LCModel basis are shown in Figure 2. The figure shows the real part of the spectra of select metabolites, superimposed with matching ICs; Inhibitors,research,lifescience,medical spectra are demeaned and intensity normalized (zero-mean, unit-norm). Shown below the spectra are the scatter plots of the estimates from ICA and LCModel plotted against ground Inhibitors,research,lifescience,medical truth-mixing coefficients. The estimates are normalized on a scale of 0 to 1 and least squares fit lines for the scatters are also shown. Note the high spectral correlations across the board and the near-perfect overlaps between the ICs and basis spectra. Also notice how well LCModel resolves Glu, Gln from simulated data, which is not common in the in vivo case. The tight scatter of LCModel estimates are not surprising, given

LCModel’s own basis spectra were used to generate the data in the first place. This shows that LCModel estimates are accurate when modeling assumptions are valid, and also validates our simulation experiment. Notice that the scatter in ICA estimates is also Inhibitors,research,lifescience,medical comparably small, with high correlation scores. Figure 2 Results from simulated Inhibitors,research,lifescience,medical data generated with LCModel spectra: Real part of select LCModel basis spectra and the matching ICs, both zero-mean, unit-norm shown; PPM scale is presented for reference only. Also shown are scatter plots of corresponding estimates, … Figure 3 captures the results from analysis of the data generated using click here GAVA basis. The real part of select LCModel and GAVA basis spectra, all with this website zero-mean and unit-norm are shown; extracted ICs closely resembling GAVA basis are not shown. Although both the models were simulated with similar sequence parameters and experimental conditions and show great similarities, their spectral patterns are not identical and the occasional lack of overlap reveals that differences exist between the models, as captured by their spectral correlations. Notice the correlations of LCModel estimates against ground truth-mixing coefficients are considerably weak when the basis spectral correlations are weak, revealing that LCModel estimates suffer when the data are not consistent with the modeling assumptions.