During learning of abstractions like categories, STR could first acquire specific associations. Category

acquisition could occur as the output of the basal ganglia trains cortical networks, which by virtue of their slower plasticity can pick up on the common features across specific exemplars and form abstract representations of the category (Miller and Buschman, 2008 and Seger and Miller, 2010). This is consistent with observations that familiar abstract rules are represented more strongly and with a shorter latency in the frontal cortex than in the STR of monkeys (Muhammad et al., 2006) and thus were more likely to be stored in the PFC. Our finding that the strongest learning-related signals in STR appeared early in S-R learning, followed by stronger engagement by the PFC during

and after category acquisition, is consistent with this hypothesis. this website In short, although our results Enzalutamide in vivo do not preclude an important role for STR in the acquisition of abstractions by the PFC, they suggest greater engagement of PFC than STR neural mechanisms during category learning per se. Data were collected from two macaque monkeys that were taken care of in accordance with the National Institutes of Health guidelines and the policies of the Massachusetts Institute of Technology Committee for Animal Care. Trials began when the animal maintained fixation on a central target for 0.7 s. After fixation, a randomly science chosen exemplar from either category was presented for 0.6 s (cue). Trials from both categories were randomly interleaved throughout the session. After the cue offset, there was a 1 s delay interval, followed by the saccade epoch, during which the fixation target was extinguished and two saccade targets appeared left and right of the center of fixation. The animal had to make a single direct saccade to the correct

target within 1 s for reward. Exemplars comprised static constellations of seven randomly located dots, generated as intermediate-level distortions of the corresponding prototype (see Supplemental Information). Simultaneous recordings from PFC and STR were performed by using two multielectrode (8–16) arrays, which were lowered at different sites every day. Spikes were sorted offline by using principal component analysis. All computations were done on MATLAB (MathWorks, Natick, MA). Neural information was computed by using the d′ sensitivity index (i.e., the absolute difference in average firing rate between two conditions normalized to their pooled standard deviation) and was calculated along a trial × time sliding window (10 trials × 100 ms). Unless otherwise noted, only correct trials were used for neurophysiological analyses. To correct for sampling bias, we randomly shuffled the trials between the two categories 1000 times and calculated the population average information for the corresponding trial-time bin for each permutation.