doi:10.1053/j.ajkd.2013.03.027.PubMedCrossRef 43. Delavenne X, Moracchini J, Laporte S, Mismetti P, Basset
T. UPLC MS/MS assay for routine quantification of dabigatran—a direct thrombin inhibitor—in human plasma. J Pharm Biomed Anal. 2012;58:152–6. doi:10.1016/j.jpba.2011.09.018.PubMedCrossRef 44. Ciulla TA, Sklar RM, Hauser SL. A simple method for DNA purification from peripheral blood. Anal Biochem. 1988;174(2):485–8.PubMedCrossRef 45. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559–75. doi:10.1086/519795.PubMedCrossRefPubMedCentral 46. Filler G, Bokenkamp A, Hofmann W, Le Bricon T, Martinez-Bru C, Grubb A. Cystatin C as a marker of GFR—history, indications, and future research. Clin Biochem. 2005;38(1):1–8. doi:10.1016/j.clinbiochem.2004.09.025.PubMedCrossRef click here 47. CBL0137 Stangier J, Feuring M. Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis. TH-302 2012;23(2):138–43. doi:10.1097/MBC.0b013e32834f1b0c.PubMedCrossRef 48. Boehringer Ingelheim Pharma GmbH
& Co. KG. Pradaxa. Summary of Product Characteristics. European Medicines Agency. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf. Accessed 5 Jan 2014. 49. Begg EJ, Chin PK. A unified pharmacokinetic only approach to individualized drug dosing. Br J Clin Pharmacol. 2012;73(3):335–9. doi:10.1111/j.1365-2125.2011.04089.x.PubMedCrossRefPubMedCentral 50. Hellden A, Odar-Cederlof I, Nilsson G, Sjoviker S, Soderstrom A, Euler M et al. Renal function estimations and dose recommendations for dabigatran, gabapentin and valaciclovir: a data simulation study focused on the
elderly. BMJ Open. 2013;3(4). doi:10.1136/bmjopen-2013-002686. 51. MacCallum PK, Mathur R, Hull SA, Saja K, Green L, Morris JK, et al. Patient safety and estimation of renal function in patients prescribed new oral anticoagulants for stroke prevention in atrial fibrillation: a cross-sectional study. BMJ Open. 2013;3(9):e003343. doi:10.1136/bmjopen-2013-003343.PubMedCrossRefPubMedCentral 52. Duffull SB, Wright DF, Al-Sallami HS, Zufferey PJ, Faed JM. Dabigatran: rational dose individualisation and monitoring guidance is needed. N Z Med J. 2012;125(1357):148–54.PubMed 53. Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, et al. Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: a RE-LY (Randomized Evaluation of Long-term Anticoagulation Therapy) trial analysis. Circulation. 2014;129(9):961–70. doi:10.1161/CIRCULATIONAHA.113.003628.PubMedCrossRef 54. Chin PK, Wright DF, Patterson DM, Doogue MP, Begg EJ. A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time.