Dark-brownish solid, M P : 284–286 °C; yield: 70%; IR (KBr, cm−1)

Light-red-colored solid, M.P.: 162–164 °C; yield: 69%; IR (KBr, cm−1): 3324 (N H), 2952 (AliC H), 1728 (C O, ketone), 1688 (C O, amide), 1592 (C C), 1343 (C N); 1H NMR (DMSO-d6) δ: 2.05 (s, 3H, CH3), 2.87 (s, 2H, CH2), 8.78 (s, 1H, Ar H), 8.93 (s, 1H, Ar H), 9.08 (s, 1H, Ar H), 9.43 (s, 1H, NH); calculated for C9H9N3O3: C, 52.17; H, 4.38; N, 20.28; found C, 52.12; H, 4.52; N, 20.33. Dark-brownish solid, M.P.: 284–286 °C; yield: 70%; IR (KBr, cm−1): 3246 (N H), 3152 NVP-LDE225 price (Ar C H), 2968 (Ali C H), 1674 (C O, amide), 1583 (C C), 1248 (O C); 1H NMR (DMSO-d6) δ: 2.09 (s, 3H, CH3), 5.45 (s, 1H, CH), 7.12–7.23 (m, 5H, Ar H), 8.78 (s, 1H, Ar H), 8.93 (s, 1H, Ar H), 9.08 (s, 1H, Ar H), 9.41 (s, 1H, NH), 9.76 (s, 1H, NH), 10.11 (s, 1H, NH); MS (m/z): (M + 1) calculated 338.12; found 338.07; calculated for C17H15N5O3: C, 60.53; H, 4.48; N, 20.76; found C, 60.48; H, 4.53; N, 20.82. Ash-colored solid, M.P.: 296–298 °C; yield: 77%; IR (KBr, cm−1): 3253 (N H), 3166 (Ar C H), 2948 (Ali C H), 1677 (C O, amide),

1584 (C C), 1888 (C S), 1192 (O C); 1H NMR (DMSO-d6) δ: 2.06 (s, 3H, CH3), 5.38 (s, 1H, CH), 7.09–7.25 (m, 5H, Ar H), 8.78 (s, 1H, Ar H), 8.93 (s, 1H, Ar H), 9.08 (s, 1H, Ar H), 9.39 (s, 1H, NH), 9.82 (s, 1H, NH), 10.08 (s, 1H, NH); MS (m/z): (M + 1) Unoprostone calculated 354.10; MK-2206 cell line found 354.04. Calculated for C17H15N5O2S: C, 57.78; H, 4.28; N, 19.82; found C, 57.83; H, 4.22; N, 19.87. Light-yellowish solid, M.P.: 313–315 °C; yield: 76%; IR

(KBr, cm−1): 3276 (N H), 3168 (Ar C H), 2984 (Ali C H), 1678 (C O, amide), 1558 (C C), 1162 (O C); 1H NMR (DMSO-d6) δ: 2.07 (s, 3H, CH3), 5.49 (s, 1H, CH), 7.39–7.43 (d, 2H, Ar H), 7.97–8.02 (d, 2H, Ar H), 8.78 (s, 1H, Ar H), 8.93 (s, 1H, Ar H), 9.08 (s, 1H, Ar H), 9.24 (s, 1H, NH), 9.68 (s, 1H, NH), 10.06 (s, 1H, NH); MS (m/z): (M + 1) calculated 383.10; found 383.15; calculated for C17H14N6O5: C, 53.40; H, 3.69; N, 21.98; found C, 53.44; H, 3.75; N, 21.94. Light-bluish solid, M.P.: 357–359 °C; yield: 71%; IR (KBr, cm−1): 3257 (N H), 3164 (Ar C H), 2971 (Ali C H), 1678 (C O, amide), 1562 (C C), 1865 (C S), 1174 (O C); 1H NMR (DMSO-d6) δ: 2.03 (s, 3H, CH3), 5.39 (s, 1H, CH), 7.42–7.47 (d, 2H, Ar H), 7.98–8.04 (d, 2H, Ar H), 8.78 (s, 1H, Ar H), 8.93 (s, 1H, Ar H), 9.08 (s, 1H, Ar H), 9.17 (s, 1H, NH), 9.61 (s, 1H, NH), 10.04 (s, 1H, NH); MS (m/z): (M + 1) calculated 399.08; found 400.03; calculated for C17H14N6O4S: C, 51.25; H, 3.54; N, 21.09; found C, 51.30; H, 3.59; N, 21.15.

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