“Chitosan microparticles (Cs-MPs) for the dissolution and oral bioavailability improvement
of curcumin (Cur) were prepared with sodium tripolyphosphate (TPP) by ionotropic gelation method. Response surface methodology (RSM) based on a three-factor, three-level Box-Behnken Design (BBD), was used to optimize the preparative conditions of Cs-MPs. The Cs-MPs were characterized for particle size distribution, morphology, X-ray diffractometry, Fourier transform infrared spectroscopy, dissolution profiles, and oral absorption. The optimum conditions were found to be: 1 % of acetic acid concentration, 0.83 of Cs/Cur ratio, 0.15 % of TPP concentration. Loading capacity, encapsulation efficiency and yield of the optimized Cs-MPs were 62.92, 95.41, and 66.20 %, respectively
with 83.60 % cumulative release and 18.45 % burst release. Solid-state characterization techniques revealed the decreased crystallinity PF-03084014 purchase nature of Cur in Cs-MPs. Cs-MPs provided an improved pharmacokinetic parameter (C-max = 782.84 ng/mL, t(max) = 3.15 h) in rats as compared with pure drug (C-max = 86.39 ng/mL, t(max) = 1.05 h).”
“This longitudinal study investigated long-term effects of a multidisciplinary rehabilitation program consisting of resistance and sensorimotor training, patient education, and stress management over 6 months in patients with chronic low back pain.
Ninety-six patients with chronic recurrent low back pain performed a multidisciplinary rehabilitation program. We assessed pain-free lumbar spine range of motion FK866 (ROM), strength of the lumbar extensor muscles, and pain by visual analog scale (VAS). Furthermore, the Roland-Morris (RM) questionnaire and SF-36 were used. The examinations were performed before and after rehabilitation, and a long-term follow-up was performed after 18 months.
All outcome measurements (ROM, VAS, RM, muscle strength, and SF-36 scores) improved significantly from baseline to the post-rehabilitation evaluation. These improvements were found to persist until a follow-up evaluation 18 months after cessation LY3023414 supplier of the intervention.
confirm the results of former studies evaluating the short-term effects of multidisciplinary rehabilitation programs. In addition, our data demonstrate that well-balanced outpatient rehabilitation programs may induce persistent improvements in muscle strength, pain, function and quality of life in patients with chronic low back pain.”
“11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) plays an important part in mediating glucocorticoid action, catalyzing the interconversion of corticosterone (B) and dehydrocorticosterone (A) in rn-dents. The aim of our study is to investigate the effects of (+)-gossypol (G+) on 11 beta-HSH. Adult ICR mice were given B and B + (G+) by intraperitoneal injection. The activity of 11 beta-HSD was evaluated by measuring the ratio of A and B, meanwhile the effects of (+)-gossypol on the conversion rate of B to A was determined with HPLC.