Body composition Total body mass (Figure 2a, b) and fat mass (Figure 3) decreased in the 1 KG group (p < 0.001) and in the 0.5 KG group (p < 0.01). The change was greater in 1 KG than in 0.5 KG in both cases (p < 0.01). There were no changes in lean body mass or bone mass. Figure 2 a -- The body mass and the change of the body mass in both groups before and after the 4-week weight reduction. ## p < 0.01, ** p < 0.01, *** p < 0.001. b-The individual VX-809 purchase body mass changes during the 4-week weight reduction period in the 0.5 KG and 1 KG groups. Figure 3 The fat mass and the change of the fat mass in both groups before and after the 4-week weight reduction. ##
p < 0.01 difference between the groups in the change from before to after Verteporfin concentration situation, ** p < 0.01, *** p < 0.001 difference from before to after situation. Hormone concentrations Serum total testosterone concentration decreased significantly from 1.8 ± 1.0 to 1.4 ± 0.9 nmol/l (p < 0.01) in 1 KG and the change was greater (p < 0.05) in 1 KG than in 0.5 KG (Figure 4). On the other hand, serum SHBG concentration increased in 1 KG from 63.4 ± 17.7 to 82.4 ± 33.0 nmol/l (p < 0.05) during the weight reducing regimen. The change in the 0.5 KG group did not reach the level of statistical significance
BIBF-1120 (Figure 5). Serum free testosterone decreased significantly only in 1 KG (p < 0.01) and the change was relatively greater (p < 0.05) in 1 KG than in 0.5 KG (Figure 6). There were no differences in serum cortisol or DHEAS concentration C-X-C chemokine receptor type 7 (CXCR-7) within or between the groups. The cortisol concentration was 577 ± 162 nmol/l in 0.5 KG and 496 ± 183 nmol/l in 1.0 KG before the weight loss. After the weight loss the concentration was 581 ± 205 nmol/l in 0.5 KG and 568 ± 170 nmol/l in 1.0 KG. The DHEAS concentration was 4.8 ± 2.4 μmol/l in 0.5 KG and 5.4 ± 5.0 μmol/l in 1.0 KG before the period. After the weight loss the concentration was 4.9 ± 2,3 μmol/l in 0.5 KG and 5.6 ± 3.0 μmol/l in 1.0 KG. Figure 4 The serum total testosterone concentration and the change of it after the 4-week weight reduction in both groups. # p < 0.05 difference between the groups in the change from
before to after situation, ** p < 0.01 difference from before to after situation. Figure 5 The SHBG concentration and the change of it after the 4-week weight reduction in both groups. * p < 0.05 difference from before to after situation. Figure 6 The serum free testosterone concentration and the change of it after the 4-week weight reduction in both groups. ** p < 0.01 difference from before to after situation, # p < 0.05 relative change (%) between the groups. Correlations The percentage change in serum testosterone concentration correlated significantly with the percentage change in body mass (r = 0.55, p = 0.033) and with the percentage change in fat mass (r = 0.52, p = .045). Also regression equations are shown (Figure 7A and 7B).