Among 117 survivors of mitral valve repair, after 18 +/- 6 months mean effective regurgitant orifice reduced from 34.1 +/- 10.2 mm(2) to 2.3 +/- 0.4 mm(2) (P < .001). Nine patients showed residual effective regurgitant orifice 10 to 19 mm(2). ABT-263 clinical trial Reverse remodeling was present in 69 patients (59.0%), no remodeling in
40 (34.1%), and continuous remodeling in 8 (6.9%). Ejection fraction changed from 37% +/- 10% to 43% +/- 10% (P <.001), improving in 47, remaining unchanged in 63, and worsening in 7.
Conclusions: Echocardiographically based strategy contributed to reduced postoperative mitral regurgitation persistence (effective regurgitant orifice >= 10 mm(2) in 7.7% of cases, with no patients showing effective regurgitant orifice >= 20 mm(2)). All patients remained in New York Heart Association functional class I or II, but more than mitral annuloplasty was performed in close to 40%. (J Thorac Cardiovasc Surg 2011;141:1150-6)”
“Differences and similarities in 3-Methyladenine order microstructural white matter alterations between bipolar I and bipolar II disorder were investigated. Twelve patients with bipolar I disorder, 12 patients with bipolar
II disorder and 22 healthy controls underwent diffusion tensor imaging. Fractional anisotropy (FA) and mean apparent diffusion coefficient (ADC) maps were compared between groups using voxel-based whole brain analyses. Both bipolar I and II groups had a FA decrease in the corpus callosum, cingulate and right prefrontal regions, and a ADC increase in the medial frontal, anterior cingulate,
insular and temporal regions, compared to controls. The bipolar I group had a FA decrease in the right temporal white matter and a ADC increase in the frontal, temporal, parietal and thalamic regions, compared to the bipolar II group. The results suggest disrupted integrity of commissural fibers and white matter in the anterior Cell press paralimbic structures in bipolar disorder. Relative sparing of the dorsal system and long association fibers may differentiate bipolar II from I disorder. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Objective: The purpose of this study was to review the long-term outcome of patients with Ebstein anomaly who underwent complete repair as neonates and young infants.
Methods: Between March 1994 and May 2010, 32 patients (23 neonates and 9 young infants) underwent surgery for Ebstein anomaly. Mean weight was 3.9 +/- 2.0 kg (range, 1.9-8.6 kg). The Great Ormond Street Echocardiography score was greater than 1.5 in 22 of the 23 neonates and greater than 1.0 in all infants. All associated cardiac defects were repaired including pulmonary atresia in 15 and ventricular septal defect in 4. Primary outcome measures included (1) early and late survival, (2) freedom from reoperation, (3) durability of tricuspid valve repair, and (4) functional status.
Results: Early survival was 78.1% (25/32). There was 1 late death. Fifteen-year survival estimate was 74% +/- 8%.