[21] In the study, VFR children were mainly born

in France (second or third generation immigrants). We speculate that their families were probably quite well assimilated, and, for this reason, might be more likely to take preventive measures.[22] Financial considerations have to be taken into account for preventive measures, as reflected by the 13% of children that did not buy atovaquone-proguanil, the most expensive drug, after counseling (data not shown). Malaria chemoprophylaxis MLN0128 is not refunded by the French national health system or by personal health insurance, and preventive treatment has to be paid for by families themselves. Monoparental status has already been associated with poor compliance with common vaccines.[23] It is frequently associated with low income, which could explain the lower compliance with chemoprophylaxis reported in this group. Finally, we cannot rule out the possibility that

this website certain chemoprophylaxis were disrupted because they were not in accordance with the local profile of malaria in the region visited. In Southeastern Asia especially, transmission may vary within a country, from one area to another. When the local epidemiology is not well known, some practitioners may overprescribe chemoprophylaxis just to be safe. It is common for travelers to disregard dietary recommendations.[12, 24] However, most parents reported drinking bottled water. As in other studies,[25] families with young children were also the most compliant with advice relating to food and water. There are certain limitations that need to be acknowledged regarding this study. To minimize recall bias, families were contacted shortly after their return, but children were invited to join

the study before departure. We cannot rule out the possibility, therefore, that knowledge of inclusion in a preventive study meant that the measure of compliance was probably higher than it might otherwise be. Furthermore, parents seeking care in a travel medicine center before departure 3-mercaptopyruvate sulfurtransferase probably worry about travel-related diseases more frequently than others, and they may be more compliant. For instance, the compliance with hepatitis A vaccination was higher in our study than in another French one taking place in mother and infant welfare services.[26] Our children are probably not representative of all children traveling abroad either. We speculate that families with poor language skills, or those poorly assimilated into French culture, for instance, do not readily visit a travel medicine center before a “tropical” journey. In our pediatric experience, they would rather visit a general practitioner closer to their residence, or travel without any counseling. The prevention of travel-related diseases in children traveling abroad depends on the ability of the family to maintain high levels of compliance before and after the trip.