0001), and both 2-APB and SKF96363, store-operated calcium channels (SOCs) inhibitors, completely inhibited ATP-induced [Ca2+]i increases after restoration Crenolanib of extracellular Ca2+. ATP promoted the proliferation and migration of HCC cells and the growth of HCC in nude mice. Suramin, P2Y2R specific siRNA, and 2-APB inhibited ATP-induced HCC cell proliferation and migration and HCC growth (P < 0.05 and P < 0.01). Conclusion: P2Y2R was up-regulated in human HCC cells and mediated ATP-induced

human HCC cell proliferation and migration and HCC growth through SOCs-mediated Ca2+ signaling, suggesting that P2Y2R may play important role in the development and progression of inflammation-associated HCC and targeting P2Y2R may be a promising therapeutic strategy against human HCC. http://www.selleckchem.com/products/DMXAA(ASA404).html Key Word(s): 1. P2Y2 receptor; 2. HCC; 3. ATP; Presenting Author: HYE JIN KIM Additional Authors: BEOM YONG YOON, SE YOUNG PARK, SE WOONG HWANG, SUN HYUNG KANG, HEE SEOK MOON, JAE KYU SEONG, EAUM SEOK LEE, SEOK HYUN KIM, BYUNG SEOK LEE, HEON YOUNG LEE Corresponding Author: HYE JIN KIM Affiliations: Chungnam National University Objective: Transarterial chemoembolization (TACE) have been applied for treating hepatocellular carcinoma (HCC), but procedure-related complications can be a serious problem. Methods: Liver abscess is most common infectious complication

during post-TACE period. Results: We describe three cases of necrotizing liver abscess after TACE in hepatocellular carcinoma. First case, a 79-year-old man, with 2.6 cm sized HCC in S4, was treated by TACE for two times during 2 months. About 1 month after the last TACE, abdominal CT scan revealed a gas containing liver abscess. Antibiotics and percutaneous transhepatic drainage was performed. Chloroambucil Cholangiography via drainage catheter showed

findings of bile duct necrosis. The patient improved condition and removed the catheter. Second case, a 68-year-old man, with four HCC in S4, 5, 7, 8, was treated by TACE for three times during 2 years. Two new lesions was found in S6/7, was performed by TACE. About 2 days later the patient had a fever and abdominal pain. Abdominal CT scan reveal a necrotizing liver abscess and percutaneous transhepatic drainage was performed. Two month later, the abscess improved and catheter removed. Third case, a 75-year-old man was performed embolization due to HCC rupture. After 1 month, abdominal CT scan revealed necrotizing liver abscess. Antibiotics and percutaneous transhepatic drainage was performed. However, the abscess persisted despite of treatment for 5 months. Conclusion: Physicians should be alerted to necrotizing liver abscess after TACE in patient with variable clinical manifestations. Key Word(s): 1. TACE; 2. HCC; 3.