0 (GraphPad Software, San Diego,

CA), and the significant differences are reported at P < 0.05. Nucleotide sequences accession number The sequences of 16S rRNA gene obtained in this study have been deposited in the GenBank database (EMBL, U.K.) under accession numbers KF515539-KF515557. Acknowledgments This work was supported by the Key Project of National Natural Science Foundation in China (30830098), National Natural Science Foundation in China (81070375), National Basic Research Program (973 Program) in China (2009CB522405), National High-tech R&D Program (863 Program) of China (2012AA021007) and Scientific Research Fund in Jiangsu Province (BK2009317). We thank Prof. Qingshun Zhao providing the zebrafish and embryos. References 1. Loftus EV Jr: Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004,126(6):1504–1517.PubMedCrossRef buy CCI-779 2. Fiocchi C: Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998,115(1):182–205.PubMedCrossRef 3. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR: Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Tariquidar Acad Sci U S A 2007,104(34):13780–13785.PubMedCentralPubMedCrossRef 4. Neish AS: Microbes in gastrointestinal health and disease. Gastroenterology 2009,136(1):65–80.PubMedCentralPubMedCrossRef

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