Efforts are concentrated on developing alternative nonopioid approaches that appear to increase the success rate
and improve patients’ quality of life.”
“Although polypropylene (PP) is the most common biomaterial used to repair genital prolapse via vaginal route, its mechanical properties however remain obscure.
An abdominal hernia rabbit model was used to evaluate retraction, solidity, and elasticity of the principal types of PP prostheses currently available, i.e., three large pore size monofilament prostheses, one heavy weight (HWPP), a second low weight (LWPP), and a third coated with atelocollagen Ferroptosis phosphorylation (CPP). A small pore size multifilament PP (MPP) implant was also tested.
In comparison with HWPP (12%), LWPP (15%), and MPP (30%), CPP had less retraction (8% of the original size). Unlike pore size, weight prosthesis is not an influencing factor for retraction. Atelocollagen coating reduced retraction. HWPP and MPP were the most solid prostheses. MPP supported the greatest elastic force.
When the AZD1152 biomechanical parameters were comparatively assessed, HWPP was considered to have the most advantageous properties
for prolapse surgery.”
“Colloidal silica particles of micrometric size are dispersed in 5CB, a nonionic nematic liquid crystal, and are glued on a glass-indium-tin-oxide substrate by means of an in situ synthesized acrylate polymer film. In order to evaluate the gluing properties of the film, we address pull-off forces in the piconewton range on the beads on applying small electric fields. This provides us with an extremely sensitive tool for studying the adhesion of the beads on the substrate. We thus determine their pull-off statistics. We show that the gluing properties of the film depend on whether the polymerization of the film is initiated via volume or surface nucleation, and whether the film is synthesized before or after the beads are deposited on the substrate. Typically, the adhesion is measured around 25 pN which nevertheless
could be interesting for particular applications.”
“Background: Chemotherapy-induced nausea and vomiting (CINV) is one of the most debilitating toxicities associated with cancer treatment. Although effective antiemetic Baf-A1 inhibitor agents are available, their use in practice often is suboptimal.
Methods: The author reviews the pathophysiology of CINV as well as the drug classes and cost considerations that should be incorporated into treatment planning.
Results: Several drug classes, including 5-hydroxytryptamine-3 receptor antagonists, neurokinin-1 receptor antagonists, and corticosteroids, are effective, especially when used in combination. Older antiemetic agents, such as prochlorperazine and metoclopramide, as well as olanzapine may provide reasonable alternatives in certain settings.
Conclusions: Interventions for CINV should include standard-of-care antiemetics combined with corticosteroids.