We defined needle-specific technical success as successful puncture of a duct or area of interest. Procedural success was defined as successful placement of a prosthesis or therapeutic injection. Clinical success was defined as resolution of collection, significant improvement in laboratory parameters and/or avoidance of any subsequent unplanned intervention. Results: A total of 158 patients (mean age 67.5, male Staurosporine order 58%) underwent 158 interventional EUS procedures using the flexible 19-gauge needle. Malignant etiology was present in 79% of patients. EUS-guided biliary drainage (54%) and pancreatic pseudocyst drainage

(22%) were the most common indications. There was no significant difference with regards to needle specific technical

or clinical success between the two groups (Table 1). However procedural success is more likely to occur with echoendoscope in the straight position. The overall complication rate was similar between the 2 groups (Table 1). Conclusion: This large multicenter study suggests that the flexible 19-gauge needle was effective for use in interventional EUS procedures with an acceptable complication rate. The needle specific technical success rate was comparable when the echoendoscope was in a straight versus angulated position. Table 1: Patient and procedure-related outcome by route of access.   Transesophageal transgastric Transduodenal transjejunal transcolonic Overall p-value Number, n (%) 100 (63.3) 58 (36.7) 158   Procedure time (mins) mean (SD) 62.2 (37.14) 70.3 (29.80) 64.5 (34.5) Selleckchem PF-562271 0.11 Mean follow up (mths) 3.99 4.06 3.97 0.48 Needle specific technical success 95 (95) 54 (93.1%) 149 (94.4%) 0.62 Procedure successfully completed 90 (90) 45 (77.6%) 135 (87.3%) GBA3 0.03 Clinical success 61 (61) 38 (65.5%) 99 (62.6%) 0.81 Complications 16 (16) 12 (20.7) 28 (17.7) 0.96 Mortality 1 (1) 0 (0) 1 (0.6) V Kumbhari,1 P Saxena,1 AC Storm,1 M Solanki,1 Okolo PI III1 1Department of Medicine and Division

of Gastroenterology and Hepatology, John Hopkins Hospital and Medical Institution, Baltimore, MD, USA Background and Aims: Surgically altered GI anatomy is increasingly encountered by the endoscopist due to the rising prevalence of bariatric surgery, liver transplant, and pancreaticoduodenectomy. The prevalence of biliary pathology is increased in these patients as bile stone formation may complicate rapid weight loss in post-bariatric patients, and post-operative biliary and enteral strictures and leaks may complicate hepatobiliary surgery. Limitations of current deep enteroscopy platforms include lack of widespread availability and limited therapeutic potential due to the smaller calibre working channel. Using a standard endoscopy platform, the Through-the-Scope Balloon Catheter (TSBC) marketed as NaviAid−AB (SMART Medical Systems Ltd.