The prevalence of resistance to oseltamivir remains low worldwide (1–2%, data not shown) and the available data for this consultation did not indicate a significantly increased proportion of oseltamivir resistant A(H1N1)pdm09

viruses Cobimetinib mouse isolated from patients not exposed to the drug compared to previous seasons (data not shown). All A(H1N1)pdm09 viruses were sensitive to zanamivir (data not shown). All but one A(H3N2) virus characterised, A/Cairo/136/2012 collected in December 2012 (S31), were resistant to adamantanes (based on the presence of the M2 protein AA substitution S31N) but all were sensitive to neuraminidase inhibitors oseltamivir and zanamivir (data not shown). Most influenza B viruses analysed were sensitive to oseltamivir and zanamivir: only one B isolate tested showed reduced inhibition by oseltamivir (data not shown). The writing committee would like to thank all of their colleagues in their institutes, the WHO NICs and other laboratories and organisations for their efforts in supplying, testing and analysing the influenza viruses characterised in the course of generating the data for this report. The

Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and the WHO Collaborating Centre buy Erlotinib for Reference and Research on Influenza at the MRC National Institute for Medical Research, Mill Hill, is supported by Medical Research Programme U1175512723. DS is supported by NIH contract HHSN266200700010C. The boundaries and names shown and the designations used in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.

Dotted lines on maps represent Mephenoxalone approximate border lines for which there may not yet be full agreement. “
“RSV is an important cause of acute lower respiratory infection in infants and elderly adults [1]. Recent estimates have shown the considerable global burden of RSV-associated disease [2] and have highlighted the need for the development of effective vaccines for use in vulnerable populations. Severe RSV infection in infants can result in the development of potentially life-threatening severe pneumonia [3] and is increasingly being recognised as predisposing to severe pneumonia in the short term [4] and as a risk factor for the development of wheeze and asthma in later life [5].